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All-in-One High Resolution 3D Optical Microscope Imaging System

技術優勢

Multi-function microscopy High-resolution imaging

技術應用

3D imaging Bioimaging Nanotechnology inspection

詳細技術說明

High-resolution 3D imaging is obtained by interpolating separate images taken of an object on each of its axes. The object is rotated and flipped in 90 degree increments, or the angle of illumination is rotated and flipped to achieve the individual 2D images. The interpolation process is applied to any 3D wave-based imager, including ones using electromagnetic waves and ultrasonic waves. The computational algorithms have been fully developed, tested, and implemented on a prototype device. The range of additional features, including measurement of birefringence, profilometry, confocal microscopy, and spectral microscopy can be combined in the form of a multi-function microscope for comprehensive imaging at high resolution.

*Abstract

Comprehensive enhancements made by researchers at the University of Central Florida improve imaging function and resolution beyond the diffraction limit of current systems. This new system combines existing imaging techniques - measuring birefringence, profilometry, confocal microscopy, and spectral microscopy - creating one system that implements the multiple methods simultaneously. This unique combination allows for unparalleled measurement of samples not previously possible while achieving high-resolution 3D imaging, by exceeding the classical diffraction limit using novel opto-mechanical techniques and software to enhance the resolution. This is particularly beneficial in bioimaging applications where samples can be observed with non-destructive optical imaging, keeping the cell alive while measuring the sample with greater clarity and resolution than existing techniques, including internal cell structures. The innovation can also be applied to liquid lens apparatuses for stabilization and reduced imaging aberration.

*Principal Investigation

Name: Nabeel Riza, Ph.D.

Department:

附加資料

Inventor: Riza, Nabeel A.
Priority Number: US7978346B1
IPC Current: G01B001122
US Class: 356627 | 356368
Assignee Applicant: University of Central Florida Research Foundation Inc.lando
Title: Methods and systems for realizing high resolution three-dimensional optical imaging
Usefulness: Methods and systems for realizing high resolution three-dimensional optical imaging
Summary: Method for realizing high resolution three-dimensional optical imaging e.g. profilometry, confocal microscopy, birefringence measurements, and spectral microscopy, of a three-dimensional object e.g. blood vessel and healthy liver tissue, for tissue targeting, nano-medicine delivery, and tissue diagnostics. Can also be used for electronic and optical chip inspection, characterization of thin films, laser crystals and plate glass for LCD, non-destructive testing (NDT) in electronic semiconductor processing, optical chip fabrication, microelectromechanical (MEMS) device inspection, photovoltaic solar panels assembly, LCD production and data storage system.
Novelty: High resolution three dimensional optical imaging e.g. profilometry, realizing method for e.g. blood vessel for tissue diagnostics, involves combining three volumetric data sets to form three-dimensional reconstructed image

主要類別

光學

細分類別

光學系統

國家/地區

美國