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Wound Healing Polymetric Networks

詳細技術說明

None

*Abstract

The inventors have developed a biodegradable and biocompatible polyurethane material for use as a tissue engineering scaffold, with a primary application for wound healing. This injectable biosynthetic material cures in seconds to an elastomeric resorbable matrix. Cure chemistry is accomplished at physiologically relevant temperatures using compounds that are at least benign, and in some cases beneficial. When catalysis is done using silver ions, the silver is distributed throughout the matrix and provides antimicrobial properties which limit the growth of bacteria, fungi and yeast which commonly infect skin wounds .Applications1) wound healing2) surgery3) in-vivo tissue engineeringAdvantages1) Liquid material can easily be injected into the affected area using a needle and syringe.2) Biocompatible mixture cures rapidly to an elastomeric solid via benign chemistry3) Antimicrobial properties accelerate healing of bacterially contaminated wounds4) Anesthetic agents can easily be added5) Material is biodegradable and resorbed by the body6) Chemistry is versatile, many biologically active molecules can be used7) Sterilization compatibleStage of Development* Proof of concept in animal modelsNon Provisional Patent Application Filed.Pending Foreign Patent Applications:Hong Kong, Europe, Canada, Australia

*Principal Investigation

Name: Stephen Badylak, Professor - Research

Department: Med-Surgery

Name: Eric Beckman, Professor

Department: Chem/Petroleum Engineering

Name: Donald Freytes, Bioengineering Graduate student

Department: Bioengineering

Name: Alan Wells, Vice Chairman

Department: Med-Pathology

Name: Jianying Zhang, Research Associate

Department: Med-Orthopedic Surgery

國家/地區

美國