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NATIVE CHEMICAL LIGATION AT SERINE AND THREONINE SITES

總結: A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (Fig. 1 (a)): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond.

附加資料: Inventor: LI, Xuechen
Priority Number: WO2011017837A1
IPC Current: C07K000102 | C07K0001107 | C07K000200
Title: NATIVE CHEMICAL LIGATION AT SERINE AND THREONINE SITES | LIGATURE CHIMIQUE NATIVE SUR LES SITES DE LA SÉRINE ET DE LA THRÉONINE
Usefulness: NATIVE CHEMICAL LIGATION AT SERINE AND THREONINE SITES | LIGATURE CHIMIQUE NATIVE SUR LES SITES DE LA SÉRINE ET DE LA THRÉONINE
Summary: Method for ligating C-terminal aryl aldehyde ester and an N-terminal serine or threonine to produce a natural peptide bond (claimed).
Novelty: Ligation of C-terminal aryl aldehyde ester and N-terminal serine or threonine to produce natural peptide bond by reacting starting peptide to form acetal intermediate, and converting acetal intermediate to desired peptide or protein

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