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Protein Sequences Containing Antigenized Antibodies for Foot-and-Mouth Disease

總結

Antibodies are proteins produced by the body!|s immune system in response to foreign elements (antigens) which invade the body. Antigenized antibodies are antibodies which are genetically engineered in their variable domain to express epitopes of different antigens. As such, antigenized antibodies can be used as an alternative approach to conventional or synthetic peptide vaccination. This new vaccine formulation is an antigenized antibody gene which elicits immunicity against foot-and-mouth disease virus.

The new FMD Vaccine is created by grafting a genetically engineered viral peptide sequence onto swine immunoglobulin(IgM) molecules. When injected into the host, it will stimulate immunogenicity against the complimentary determining regions(CDR) of the FMD virus. It overcame the problem with conventional FMD vaccine using inactive virus, which are proven inefficient and expensive. The fact that the new FMD Vaccines does not contain a viral RNA eliminated potential safety problem with possible not completely inactivated virus in conventional vaccines that can therefore cause the disease to spread.

Foot-and-Mouth Disease(FMD) is a highly contagious, severely debilitating disease which infects all cloven-hoofed animals. It is endemic in many developing countries in Asia, Africa, and parts of South America. To the swine growing business, FMD reduces livestock productivity, incurs high vaccination costs, and restricts the international trade of livestock and products. The economic loss of one pig farm in Hong Kong at the outbreak of FMD can reach HK$2,000,000.

技術優勢

1. Low manufacturing cost
2. High production yield
3. High efficacy
4. No live virus involve and so higher safety factor
5. Can be adapted to cope with viral mutation and so wider protection range
6. High quality products using less production time

技術應用

- Foot-And-Mouth Disease Vaccine

附加資料

Patent Number: US7374763B2
Application Number: US2004915121A
Inventor: Yong, Xie
Priority Date: 15 Apr 1999
Priority Number: US7374763B2
Application Date: 9 Aug 2004
Publication Date: 20 May 2008
IPC Current: A61K003900 | A61K003800 | A61K003942 | C07K001608 | C12N000506 | C12P002106
US Class: 4241841 | 4241851 | 4241921 | 4350691 | 530300 | 530806
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Protein sequences containing antigenized antibodies for foot-and-mouth disease
Usefulness: Protein sequences containing antigenized antibodies for foot-and-mouth disease
Summary: (I) is useful for eliciting immune system response against FMD in swine (claimed).
Novelty: Novel vaccine for foot-and-mouth disease in swine, comprises construct of foot-and-mouth disease virus epitopes of cDNA or their protein counterparts

主要類別

生物醫學

細分類別

病原

申請日期

9 Aug 2004

申請號碼

US 10/915121

專利信息

US 7374763

ID號碼

TTC.PA.074

國家/地區

香港