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E. coli C1 strain for Intramammary Sensitization of Dairy Cows

详细技术说明

The disclosure relates to a bacterial ghost E. coli C1 used for intramammary sensitization that may improve theoutcome of an intramammary infection in late gestation.

*Abstract

Clinical Mastitis is one of the most common and very costly challengesto the dairy industry. Approximately 40% of clinical mastitis cases areattributed to gram-negative, mostly coliform, bacterial infection.

 

In a randomized controlled study, Cornell researchers have used aUV-killed strain C1 of E. coli for intramammarysensitization of dairy cows. Their vaccination strategy using this strainresulted in a lower probability of infection, a lower bacteria count, lowersomatic cell counts and milk conductivity, a lower clinical mastitis score,increased milk production and a triggered mucosal immunity in the mammarygland.

 

PotentialApplications

• Canbe used to protect against late gestation intramammary infection in dairy cows;
• Canbe used for challenge studies with the homologous E. coli C1 strain.

 

Advantages

• Lowerprobability of infection;
• Lowerbacteria count;
• Lowersomatic cell counts and milk conductivity;
• Lowerclinical mastitis score;
• Increasedmilk production;
• Triggered mucosalimmunity in the mammary gland.

 

*Licensing

Phillip Owhpo62@cornell.edu1-607-254-4508

其他

国家/地区

美国