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Hexachlorophene for the Treatment of ALS and Related Disorders

技术优势

Endogenous TDP-43 accumulation is decreasedOverexpressed TDP-43 accumulation is decreasedTreatment option for ALS

技术应用

therapeutic agent for ALS

详细技术说明

Accumulation of TDP-43 protein is a major causative agent for the pathogenesis of ALS and other neurodegenerative diseases. So far, there is no cure or treatment for diseases related to TDP-43.To identify drug candidates that are capable of targeting TDP-43, two different cell based TDP-43 models were used: cells expressing endogenous TDP-43 protein and cells overexpressing wild-type human TDP-43. Hexachlorophene showed a dramatic reduction in both endogenous as well as overexpressed TDP-43 levels. Hexachlorophene could therefore serve as a potential therapeutic agent for the treatment of ALS and other related disorders.

*Abstract

The University of South Florida has discovered a potential therapeutic agent for amyotrophic lateral sclerosis (ALS) and other related disorders using the compound hexachlorophene.

国家/地区

美国