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Ultra-sensitive androgen assay

技术优势

Monitoring androgen levels is crucial for several patients. In 2006, 648,000 American men were treated for testosterone deficiency and >200,000 men were diagnosed with prostate cancer. 4-12% of American women of reproductive age suffer from polycysic ovary disease (PSOS), for which increased testosterone is a diagnostic criterion. Although decreasing in frequency, anabolic steroid abuse is still a problem. Furthermore, there is an increased need for monitoring androgen levels in the environment. Current liquid chromatography/mass spectrometry (LC/MS) techniques to measure androgen levels are costly.

技术应用

-       Monitor androgen levels in     o    men with testosterone deficiency      o    prostate cancer patients being treated with anti-androgens-       Diagnose PSOS-       Detect steroid use in athletes

详细技术说明

This assay relies on the concept that the androgen receptor (AR) translocates from the cytoplasm to the nucleus when androgens are present. Patient samples are applied to cells that express androgen receptor tagged with a yellow fluorophore and a nuclear localization sequence fused to a red fluorophore. If androgens are present, yellow fluorescence overlaps with red fluorescence. The results obtained with this assay correlated with results from the same samples analyzed by standard LC/MS techniques.

*Abstract

This invention is a novel assay to detect and quantify androgen levels, as low as 1.5 ng/dl, in blood or serum samples.

*IP Issue Date

Oct 1, 2015

*Principal Investigation

Name: Frederick Schaufele

Department:

申请号码

WO2015148549

其他

Stage of Development

Fully developed diagnostic

Looking for Partners

To commercialize this diagnostic tool

Data Availability

Under NDA/CDA

Inventor's Profile

http://profiles.ucsf.edu/fred.schaufele

Tech ID/UC Case

24133/2014-057-0

Related Cases

2014-057-0

国家/地区

美国