Site Specific Integration of Recombinant AAV Vector Genomes by Rep68 Protein Expressed on the Surface of AAV Particles
- 详细技术说明
- None
- *Abstract
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Recombinant AAV vectors are useful tools forefficient gene delivery and expression of therapeutic genes. To allow forefficient packaging of therapeutic genes into recombinant AAV particles, thenormal AAV (rep and cap) genes are removed from the viral genome and theproteins are supplied by plasmids in trans. To allow for efficient delivery ofRep protein in combination with recombinant AAV vector genomes, Researchers atNationwide Children's Hospital have developed a novel way of delivering afunctional rep protein into the nucleus for efficient integration of the AAVgenome.
- *Inquiry
- Andrew CorrisThe Research Institute at Nationwide Children’s HospitalOffice of Technology Commercialization700 Children’s DriveColumbus, OH 43205T: (614) 355-1604 F: (614) 722-2716Andrew.Corris@nationdwidechildrens.org
- *IP Issue Date
- None
- *IP Type
- Other Patent
- 国家
- Not Available
- 申请号码
- None
- 国家/地区
- 美国
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