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Polyketide Synthase Variants And Uses Thereof

技术应用: Chemical compound production, gene expression, applications include materials synthesis, antibiotics, immune-suppression, anti-cancer, therapeutic agents, cellulosic ethanol production processes, biofuel enzymes, food enzymes.

详细技术说明: Polyketides are a class of compounds that include antibiotics, immune-suppressants and anticancer agents. Polyketide synthase is a naturally occurring enzyme or engineered enzyme which can be used to prepare commercially useful chemical compounds. Applications of the polyketide synthase variant is applicable in the production of food additives, plasticizers, phytochemicals and phytochemical mixes, etc. Variants of polyketide synthases can have altered capabilities that could expand the enzymatic toolbox for enzyme-based chemical synthesis, and can demonstrate increased enzymatic activity. Efficient methods for production of polyketide synthase variants are needed. he inventors have developed the following: · Efficient methods for production of polyketide synthase variants; · Polyketide synthase variants that have increased activity, stability and solubility;

*Abstract: Polyketide synthases are multifunctional enzymes that catalyze the biosynthesis of polyketides. These enzymes make attractive targets because they can be modified to produce commodity chemicals. The invention herein describes methods for producing polyketide synthase variants whose activity and/or substrate specificity can be tailored. An example of a polyketide synthase variant would be 2-pyrone synthase, which produces 2-pyrone. Other modified synthase variants can be generated to produce other key materials including ketides, lactones, etc.

*Principal Investigation: Name: Marianne Bowman
Department:

Name: Javier Cardenas
Department:

Name: Nancy Da Silva
Department:

Name: Gordon Louie
Department:

Name: Joseph Noel
Department:

Name: Kate Woods
Department:

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