Coil Radio-Frequency Ablation
- 技术应用
- Ablationof bone tumors, specifically metastatic spinal tumors ; potentially others(vertebroplasty-compatible)Bothsmall and large soft tissue tumor ablation in the liver, kidney and breast witha single insertion
- 详细技术说明
- Clinically tested, single-insertion, minimallyinvasive radiofrequency ablation (RFA) device for treatment of bone and softtissue tumors.
- *Abstract
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This invention addresses unmetneeds in the field of RFA for treating tumors in two broad categories: 1)Spinal metastases, where it aims to address the problems of incomplete ablation(cold zones), long treatment times, and large surgical exposure; and 2) Softtissue tumors in kidney, liver and breast. RFA has been a rapidly growingtreatment modality for tumors but has the following limitations:
- It is not effective in complete tumor ablation,specifically large tumors >3cm
- Existing RFA devices require multiple cycles andoverlapping ablations, increasing treatment times
- Ablation volume is significantly reduced fromex-vivo to in-vivo settings in existing RFA device designs, largely due to heatsink effects of perfusion.
The novel helical coil design ofthe RFA device, excited with a radio frequency of 27.12 MHz (as opposed toconventional RFA devices operating at 450-500 KHz), produces electric fieldsboth in the core and around the coil that are less susceptible to theconduction and heat loss effects of blood flow (perfusion). The amount of heatgenerated is thus able to effectively ablate large tumors in a relativelyshorter span of time through a single minimally invasive insertion. Theeffectiveness of this device comes from a combination of the helical design andthe higher frequency. The device offers a minimally invasive approach to tumordebulking through rapid and uniform heat delivery and provides the option to doa percutaneous vertebroplasty after the RFA procedure in bone. The combinedspine and soft-tissue tumor ablation market is $264M and growing at a 12% CAGR.
- *Principal Investigation
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Drs. Michael Sherar, Kieran Murphy, University Health Network;
Dr. Claire McCann, Sunnybrook Health SciencesCenter
- *Publications
- “RadiofrequencyCoil for the Creation of Large Ablations: Ex Vivo and In VivoTesting”,Miller,etal,JVIR2012;23:1522-1528“Helical coilelectrode radiofrequency ablation designed for application in osteolyticvertebral tumors—initial evaluation in a porcine model,” Pezeshki et. al., TheSpine Journal 2015; 15(8): 1832–1840.The use of a dispersive ground electrode with a loosely wound helicalcoil for interstitial radiofrequency thermal therapy, Claire McCann and Michael Sherar, Physics in medicine and Biology2006, Vol.51, No.15 Development of a novel loosely wound helical coil for interstitialradiofrequency thermal therapy, Claire McCann and Michael Sherar, Physics in medicine and Biology 2006,Vol.51, No.15
- 国家/地区
- 美国
