Prophylaxis or Treatment of Feline Coronavirus Infection
- 详细技术说明
- This technology describes a novel method that may offer a cure forfeline infectious peritonitis virus (FIPV).
- *Abstract
-
Feline coronavirus (FCoV) infection in >90% of infected cats results in only mild and often inapparent enteritis. This form of FCoV is referred to as feline enteric coronavirus (FECV). However, in a small number of animals, FECV mutates into a form that confers it with the ability to infect macrophages and monocytes. It is this mutated form of the virus, called feline infectious peritonitis virus (FIPV) that leads to feline infectious peritonitis (FIP) - a lethal infection in cats and the most feared disease in catteries, for which there is no effective treatment.
Cornell researchers have developed a novel treatment paradigm for FIP and suppression of FCoV infection more generally. Specifically, differential cleavage by different cysteine proteases of the viral spike protein involved in viral entry was shown to be a critical factor in explaining the different pathogenic properties of FECV and FIPV. As such, FIPV treatment and suppression of FCoV infections more generally may be possible using cysteine protease inhibitors that target specific cysteine proteases.
Potential Applications
Treatment of FCoV and FIPV infection in cats
For more details, you arewelcome to download the technology brief.
- *Licensing
- Phillip Owhpo62@cornell.edu607-254-4508
- 其他
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- U.S.patent number 9,044,486.
- ReganAD & al. (2008). Differential role for low pH and cathepsin-mediatedcleavage of the viral spike protein during entry of serotype II felinecoronaviruses. Vet Microbiol. Dec10;132(3-4):235-48. doi: 10.1016/j.vetmic.2008.05.019.
- 国家/地区
- 美国
