Production of Malarial Surface Proteins in Algae for Use as Transmission Blocking Vaccine Candidates
- 详细技术说明
- None
- *Abstract
-
P. falciparum surface proteins have been shown to block transmission of malaria. Producing them in algae results in proteins that are correctly folded and not glycosylated, so they are more similar to the native proteins than those produced in bacterial or mammalian systems. In order to produce them for use as vaccine candidates, they will need to be produced in an inexpensive expression system that does not require much, if any, post-production modification and algae chloroplasts provide a viable approach.
SAMPLE DATA
- *IP Issue Date
- Aug 23, 2016
- *Principal Investigation
-
Name: Michael Hannon
Department:
Name: Stephen Mayfield
Department:
Name: James Gregory
Department:
Name: Carla Jones
Department:
- 申请号码
- 9422347
- 其他
-
State Of Development
Proof of concept: Multiple proteins have been produced in algal chloroplasts. Two have been tested and demonstrated correct folding and present the authentic antigen.
Related Materials
Tech ID/UC Case
23648/2011-360-0
Related Cases
2011-360-0
- 国家/地区
- 美国
