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Biodegradable Luminescent Porous Silicon Nanoparticles for In Vivo Applications

详细技术说明

UC San Diego researchers have developed luminescent porous silicon nanoparticles (LPSiNP) that can carry a drug payload and whose intrinsic near-infrared photoluminescence allows in-vivo monitoring of accumulation and degradation. Unlike most optically active nanomaterials (e.g., carbon nanotubes, gold nanoparticles, quantum dots), LPSiNP self-destruct into renally cleared components relatively quickly with little evidence of toxicity. The invention also provides imaging agents (e.g., tumor imaging using dextran-coated LPSiNP). It presents a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications.

*Abstract

Nanomaterials that can circulate in the body hold great potential to diagnose and treat disease. For such applications, it is important that the nanomaterials be harmlessly eliminated from the body in a reasonable period of time after they carry out their diagnostic or therapeutic function. Despite efforts to improve their targeting efficiency, significant quantities of systemically administered nanomaterials are cleared by the mononuclear phagocytic system before finding their targets, increasing the likelihood of unintended acute or chronic toxicity. However, there has been little effort to engineer the self-destruction of errant nanoparticles into non-toxic, systemically eliminated products.

*Principal Investigation

Name: Luo Gu

Department:

Name: Ji-Ho Park

Department:

Name: Michael Sailor

Department:

附加资料

Patent Number: US20110300222A1
Application Number: US13202271A
Inventor: Sailor, Michael J. | Gu, Luo | Park, Ji-Ho
Priority Date: 20 Feb 2009
Priority Number: US20110300222A1
Application Date: 18 Aug 2011
Publication Date: 8 Dec 2011
IPC Current: A61K000916 | A61K000900 | A61K004700 | B32B000516 | C01B003312 | C12Q000102 | B82Y000500 | B82Y004000
US Class: 424493 | 423335 | 424400 | 424490 | 428402 | 435029 | 514770 | 977700 | 977895 | 977927
Assignee Applicant: The Regents of the University of California
Title: LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME
Usefulness: LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME
Summary: Biodegradable porous nanostructure used as biodegradable imaging agent or used for preparing pharmaceutical composition (claimed).
Novelty: Biodegradable porous nanostructure used as biodegradable imaging agent or used for preparing pharmaceutical composition, comprises silicon material and having predetermined emission spectra and excitation spectra

主要类别

化工/材料

细分类别

纳米材料

其他

Related Materials

• Park, J.-H.; Gu, L.; Maltzahn, G. v.; Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J., "Biodegradable Luminescent Porous Silicon Nanoparticles for In Vivo Applications." Nature Mater. 2009, 8, 331-336.
• Safer Nanoparticles SpotlightTumors, Deliver Drugs, see the following two links:
  http://ucsdnews.ucsd.edu/newsrel/science/02-09safenano.asp
  http://ucsdnews.ucsd.edu/video/safenano.html
• NSF Discovery: Safer Nano Cancer Detector

Intellectual Property Info

This invention has patent pending and is available for sponsored research and/or licensing.

Tech ID/UC Case

20975/2009-246-0

Related Cases

2009-246-0

国家/地区

美国