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Transgenic Mice Over-Expressing Caveolin-3 (M-Caveolin) within the Cardiac Myocyte

详细技术说明: Caveolins are the principal protein components of caveolae, or “little caves,” which are 50 to 100 nm invaginations found in most cell types and represent appendages or subcompartments of plasma membranes. UC San Diego researchers have created a transgenic mouse for over-expressing caveolin-3 (M-caveolin) specifically within the cardiac myocyte. Caveolin-3 is one of the proteins that regulate signaling pathways and is thought to function in cardiac protection (ischemic preconditioning). Associated studies indicate that the novel caveolin-3 over-expressing mouse is resistant to myocardial ischemia/reperfusion injury, suggesting that caveolin-3 as a potential therapeutic for patients undergoing cardiac surgery or at high risk for myocardial infarction.

*Principal Investigation: Name: Brian Head
Department:

Name: Brian Head
Department:

Name: Paul Insel
Department:

Name: Hemal Patel
Department:

Name: Hemal Patel
Department:

Name: Piyush Patel
Department:

Name: Piyush Patel
Department:

Name: David Roth
Department:

Name: David Roth
Department:

Name: Yasuo Tsutsumi
Department:

Name: Yasuo Tsutsumi
Department:

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