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Device and Method for Controlled Ablation of Microscopic Objects

技术应用: The method developed by the University of California, Irvine researchers provides a new modality that offers distinct advantages to previous methods. The advantages of the present invention include: fast, patterned linear ablation of microscopic objects, simple operation, high throughput in a uniform manner, and is less expensive. The invention can be used in both research and clinical settings and makes an effective tool available to researchers for the study of molecular mechanisms of biological systems.

详细技术说明: Researchers at the University of California, Irvine, have developed a device and method that uses a spatially shaped laser beam for micro-dissection, alteration/ablation, and excitation of living/non-living microscopic objects with high throughput. The purpose of this invention is to develop a device for fast patterned linear ablation of microscopic objects, which is simple to operate and provides high throughput in a uniform manner.

*Abstract: Laser scissors use lasers to alter and/or to ablate intracellular organelles, cellular and tissue samples, and today has become an important tool for cell biologists to study the molecular mechanism of complex biological systems. Single cells or groups of cells have been perforated for injection of exogenous materials, induction of DNA damage in cells, micro-dissection of neuronal processes, as well as other intra-cellular organelles such as chromosomes or microtubules. Clinically, laser scissors have been used to reduce the thickness of the zona pellucida layer of the ovum in order to improve human in vitro fertility. In these applications, either a scanning stage or scanning mirror was used to scan a region in a single cell or group of cells for micro-processing. This method is expensive and requires complex control of the scanning beam via computer. In addition, the processing time can be lengthy and reduces the throughput of the laser microbeam system.

*Principal Investigation: Name: Michael Berns
Department:

Name: Suzanne Genc
Department:

Name: Khyati Mohanty
Department:

Name: Jared Stephens
Department:

附加资料: Patent Number: US8571365B2
Application Number: US2009613472A
Inventor: Mohanty, Samarendra K. | Stephens, Jared | Berns, Michael W.
Priority Date: 5 Nov 2008
Priority Number: US8571365B2
Application Date: 5 Nov 2009
Publication Date: 29 Oct 2013
IPC Current: G02B000626 | G02B000642
US Class: 385038 | 385033 | 604020 | 604021 | 606015 | 606016 | 606017
Assignee Applicant: The Regents of the University of California
Title: Apparatus and method for micromanipulation of microscale objects using laser light delivered through a single optical fiber and axicon lens
Usefulness: Apparatus and method for micromanipulation of microscale objects using laser light delivered through a single optical fiber and axicon lens
Summary: Apparatus for micromanipulation of microscale objects using a laser light. Uses include but are not limited to induction of deoxyribonucleic acid (DNA) damage, dissection of neuronal axons, micro-dissection of organelles such as microtubules, thinning of zona pellucida for use in reproductive medicine, and optoporation of exogenous material into cells.
Novelty: Apparatus for e.g. micromanipulation of microscale objects, has axicon lens optically coupled to fiber to form tip to provide spatially shaped elongated laser focused spot for microprocessing and/or microdissection of microscale object

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