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A NOVEL METHOD FOR THE CRYOPRESERVATION OF CELLS CONTAINING A CYTOSKELETAL NETWORK

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*Abstract

University of MissouriOffice of Technology Management & Industry RelationsNon-Confidential Abstract of InventionUM Disclosure No. 07UMC024NOVEL METHOD FOR THE CRYOPRESERVATION OF CELLS CONTAINING A CYTOSKELETAL NETWORKCryopreservation is a process where cells or whole tissues are preserved by cooling to low sub-zero temperatures, such as (typically) 77 K or ?196 °C (the boiling point of liquid nitrogen). At these low temperatures, any biological activity, including the biochemical reactions that would lead to cell death, is effectively stopped. The cells can be resuscitated by warming. However, for many cells, cryopreservation methods remain unavailable and represent a challenging problem. The present invention provides a novel method that minimizes damage to cells during cryopreservation due to physical factors associated with the cell’s cytoskeletal network. The present invention aims to minimize the impact of the mechanical stress on cells.POTENTIAL AREAS OF APPLICATIONS:• Cryopreservation of cells MAIN ADVANTAGES OF INVENTION:• Minimizes damage to cells during cryopreservation• Prevents damage of cytoskeletal network• Higher rate of cryosurvival in cellsSTATE OF DEVELOPMENT:• Technique has already been establishedFURTHER R&D REQUIRED:• Assessment of developmental competence of cellsLICENSING POTENTIAL:• University seeks licensee with the potential to commercializePATENT STATUS:• Provisional application on fileINVENTOR(S):• John K Crister, Gabor Forgacs, Basarab G H Pawtucket, Steven Francis Mullen CONTACT INFO: Office of Technology Management & Industry Relations Charlene Boyes, Sr. Licensing & Business Development Associate- Life Sciences Email: boyesc@missouri.edu Phone: 573-882-5016

*Principal Investigation

Name: John Critser Credit Shelter Trust, c/o Alex LaBrunerie, Co-Trustee

Department:

Name: Gabor Forgacs

Department:

Name: Basarab Hosu

Department:

Name: Steven Mullen

Department:

其他

国家/地区

美国