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Telomere Truncation Mediated Artificial Chromosome Production in Plants

标题

Plant Artificial Chromosome Platforms Via Telomere Truncation

详细技术说明

None

*Abstract

Engineered Minichromosomes in PlantsThe use of genetically modified crops is constantly finding new areas of application, including the production of compounds with therapeutic value. Current technology for producing transgenic crops relies on random integrations that can have variable expression and could potentially disrupt the endogenous genes. Also, combining multiple transgenes requires a lengthy crossing scheme and can bring along linked genes from one variety into another.The current invention developed by researchers at the University of Missouri is a technology that will allow continued addition of transgenes as the need arises using engineered plant minichromosomes. Artificial chromosome platforms were produced by telomere-mediated truncation while simultaneously adding DNA sequences that will permit amendments to the chromosome indefinitely. These minichromosomes can be used as a vector for efficient stacking of multiple genes for insect, bacterial and fungal resistances together with herbicide tolerance and crop quality traits unlinked to endogenous genes in a circumstance that would foster faithful expression. POTENTIAL AREAS OF APPLICATIONS:- Genetically engineered cropsMAIN ADVANTAGES OF INVENTION:- No limit to number of genes stacked- Can be combined with haploid breeding procedures- Can be used for most plant species- Can be used for dosage manipulationSTATE OF DEVELOPMENTReady to useLICENSING POTENTIALUniversity seeks licensee with potential to commercializePATENT STATUS: US patent issuedTECHNOLOGY INNOVATORSJames A. Birchler, Weichang Yu, Juan M. VegaTECHNOLOGY MANAGER CONTACTSamuel E. Bish, PhD; bishs@missouri.edu; 573-882-5016

*IP Issue Date

Aug 9, 2011

*IP Publication Date

Dec 27, 2007

*Principal Investigation

Name: Weichang Yu, former MU research fellow, 2002-2007

Department:

Name: James Birchler, Professor of Biological Sciences

Department:

申请日期

May 9, 2007

申请号码

7,993,913

其他

国家/地区

美国