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Multiplexed Point-of-Care Breast Cancer Marker Detection System

技术应用: Automated, point-of-care protein array-based immunoassay device capable of sensitive, simultaneous detection of multiple breast cancer markers Multiplex immunoassay technology for point-of-care diagnostic applications

详细技术说明: The presence and advancement of tumors has been shown to be associated with the expression of certain molecular markers. However, currently no single ideal marker exists for breast cancer. Researchers at the University of California, Davis and the Lawrence Livermore National Laboratory (LLNL) have developed a multiplexed immunoassay to measure a panel of five related molecular markers to achieve more relevant and reliable information for diagnosis of breast cancer. Compared to current breast cancer detection methods, which are associated with long wait times, high costs, skilled labor, physical and psychological trauma and low accuracy, UC Davis and LLNL researchers have developed a rapid, cost effective, disposable, sensitive microarray based device capable of detecting the multiplexed panel of markers. In addition, UC Davis and LLNL researchers are also modeling the interaction of antigen and antibody in this type of an immunoassay and the effect of flow on the reaction rates in this device.

*Abstract: Researchers at the University of California, Davis and the Lawrence Livermore National Laboratory have developed a multiplexed immunoassay to measure a panel of five related molecular markers to achieve more relevant and reliable information for diagnosis of breast cancer

*Principal Investigation: Name: Joanna Albala
Department:

Name: Abdul Barakat
Department:

Name: Helen Chew
Department:

Name: Matthew Coleman
Department:

Name: Jeffrey Gregg
Department:

Name: Imran Khan
Department:

Name: Stephen Lane
Department:

Name: Stephen Lane
Department:

Name: Paul Luciw
Department:

Name: Dennis Matthews
Department:

Name: Dennis Matthews
Department:

Name: Rupa Rao
Department:

Name: Marianne Simoes De Carvalho-K
Department:

Name: Steven Visuri
Department:

附加资料: Patent Number: US20080200342A1
Application Number: US200831625A
Inventor: Rao, Rupa S. | Lane, Stephen M. | Matthews, Dennis L. | Coleman, Matthew A.
Priority Date: 15 Feb 2007
Priority Number: US20080200342A1
Application Date: 14 Feb 2008
Publication Date: 21 Aug 2008
IPC Current: C40B003004 | C40B003000 | C40B006012
US Class: 506009 | 506007 | 506039
Title: Device, Array, And Methods For Disease Detection And Analysis
Usefulness: Device, Array, And Methods For Disease Detection And Analysis
Summary: The device is useful for determining the presence or absence of biomarkers in a sample (claimed). It can also be used for scoring a sample for diagnosing a disease.
Novelty: New detection device comprises solid support, vertical support, and absorbent material, useful for determining the presence or absence of biomarkers in a sample and for scoring a sample for diagnosing a disease

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