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Thermoresponsive biodegradable polymers with tunable temperature-dependent solubility

总结

Targeted drug delivery is being explored as an alternative to chemotherapy in cancer treatment. While many anti-cancer agents have been identified, applications have been limited due to temperature sensitivity and cytotoxicity of the carrier polymer. This technology describes methods for creating biodegradable polyacetal-based polymers with a specified lower critical solution temperature (LCST). This technology provides pathways for delivery of a range of novel pharmaceutical agents.

技术优势

Simple chemical synthesis methodsHighly predictable and tunable release of cargo over a temperature range of 6-80°CRapid phase transition and release of cargo within 3-5°C targets hyperthermic cancer environmentsBiodegradable in mildly acidic conditionsNon-toxic byproducts after pH induced degradationControllable degradation conditionsPolymer chain-end functionality for versatility beyond cancer therapiesPatent Information:Patent Pending (WO/2016/090103)Tech Ventures Reference: IR CU14314

技术应用

Anti-cancer therapeuticsTargeted drug deliveryTherapeutics for crops, plants or seeds

详细技术说明

None

*Abstract

None

*Inquiry

Satish RaoColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU14314

*Principal Investigation

*Publications

[Samanta, S., Bogdanowicz, D. R., Lu, H. H., & Koberstein, J. T. “Polyacetals: Water-Soluble, pH-Degradable Polymers with Extraordinary Temperature Response.” Macromolecules. Feb 2016 49(5), 1858-1864.] ( )

国家/地区

美国