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Diagnostic system for pre-symptomatic detection of osteoarthritis

总结

Osteoarthritis (OA), a disease hallmarked by the degeneration of cartilage in the joints, affects 80% of the elderly population. By the time OA is symptomatic, the disease is too far progressed for reversal by current medical treatments. These therapies seek only to manage symptoms, and in some cases, full replacement of the joint may be the only treatment option. Early detection of OA may allow for interventions that can stall or reverse the disease; however, there are currently no methods available for detecting pre-symptomatic signs of OA. This technology is a diagnostic system that uses computed tomography (CT) to monitor and assess the pathology of OA before symptoms arise. This system allows for early detection of OA and may enable early enough intervention to prevent further disease progression.

技术优势

Highly sensitive, high-resolutionCan detect trabecular bone resorption before other OA symptoms ariseAllows for pre-symptomatic detection of OA in at-risk patientsPatent Information:Patent Pending (US 20160331339)Tech Ventures Reference: IR CU15267

技术应用

Pre-symptomatic detection of osteoarthritis (OA)Tool for monitoring the progress of OATool for evaluating both pre- and post-symptomatic interventions against OADiagnosis of OAResearch tool for studying OA pathology

详细技术说明

None

*Abstract

None

*Inquiry

Richard NguyenColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

cu15267

*Principal Investigation

*Publications

Chen Y, Wang T, Guan M, Zhao W, Leung FK, Pan H, Cao X, Guo XE, Lu WW. “Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis.” Osteoarthritis Cartilage. 2015 Dec;23(12):2174-83.Wang H, Liu XS, Zhou B, Wang J, Ji B, Huang Y, Hwang KC, Guo XE. “Accuracy of individual trabecula segmentation based plate and rod finite element models in idealized trabecular bone microstructure.” J Biomech Eng. 2013 Apr;135(4):044502.Wang H, Ji B, Liu XS, Guo XE, Huang Y, Hwang KC. “Analysis of microstructural and mechanical alterations of trabecular bone in a simulated three-dimensional remodeling process.” J Biomech. 2012 Sep 21;45(14):2417-25.

国家/地区

美国