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Single nucleotide polymorphism and short tandem repeat detection using carbon nanotubes

总结

DNA sequences among individuals are unique in part due to mutations and variations such as single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs). These minor changes lead to severe genetic disorders, trait expression, and differences in drug reactions. Techniques that determine an individual's SNP and STR pattern can provide crucial information to healthcare providers, allowing for personalized medical regimens to optimize care. However, current techniques are time consuming and expensive. This technology describes a method to detect such SNPs and STRs by measuring the electrical signals of an individual's DNA via carbon nanotubes. Changes in conductivity allow researchers to determine variations in DNA. Potentially, the technology can be used as a diagnostic tool to determine genetic differences that can lead to more accurate diagnoses and individualized treatment plans.

技术优势

More efficient, real-time nucleotide analysisLower development costs compared to other nucleotide detection methodsSensitive and reliablePatent Information:Patent Pending (US 20110275062 A1)Tech Ventures Reference: IR M08-098

技术应用

MicroarraysDNA hybridization and binding researchGenotypingPersonalized pharmacological recommendations based on SNP analysisShort tandem repeat analysis

详细技术说明

None

*Abstract

None

*Inquiry

Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

M08-098

*Principal Investigation

*Publications

Guo X, Gorodetsky AA, Hone J, Barton JK, Nuckolls C. "Conductivity of a single DNA duplex bridging a carbon nanotube gap." Nature Nanotech. 2008 Feb 10;3:163-167.

国家/地区

美国