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Protein Therapy for Acute Lung Injury

技术优势

Direct treatment of ARDSCan utilize a number of commercially-available transport proteins such as Chariot, perpetratin, and thrombin-antithrombin (TAT) fragmentFAKp may be fused to a histidine tag which can be linked to a variety of metals including copper, nickel, and zincMay be administered through an intravenous, buccal, parenteral, or oral route, or via inhalation

技术应用

Treatment of

详细技术说明

ARDS is characterized by the hyperpermeability of air sacs to fluid. This technology consists of a protein, focal adhesion kinase (FAKp), which prevents the endothelial cells of the lungs from becoming hyperpermeable. When delivered intravenously by ...

*Abstract

None

*Inquiry

Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

2235

*Principal Investigation

*Publications

Quadri, S., and Bhattacharya, J. 2007. Resealing of Endothelial Junctions by Focal Adhesion Kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 292:L334-42. Safdar, Z., Yiming, M., Grunig, G., and Bhattacharya, J. 2005. Inhibition of Acid-induced Lung Injury by Hyperosmolar Sucrose in Rats. Am. J. Resp. and Crit. Care Med. 172: 1002-1007. Quadri, S., Bhattacharjee, M., Parthasarathi, K., Tanita, T., and Bhattacharya, J. 2003. Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase. J. Bio. Chem. 278: 13342-13349. Safdar, Z., Wang, P., Ichimura, H., Issekutz, A.C., Quadri, S., and Bhattacharya J. 2003. Hyperosmolarity enhances the lung capillary barrier. J. of Clin. Invest. 112(10): 1541-1549.

*Web Links

WIPO: WO/2009/046129

国家/地区

美国