Method to Enhance Recombinant Protein Production in Chinese Hamster Ovary (CHO) Cells for Biopharmaceutical Applications
- 详细技术说明
- Chinese hamster ovary (CHO) cells are the mostcommonly used mammalian cell line for production of biopharmaceuticalproteins. The recent developmentof genome-scale technologies permits direct cell engineering by manipulatingsingle genes that play important roles in metabolic or regulatory pathways togenerate high-producing cell lines. RNA interference (RNAi), induced in mammalian cells via smallinterfering RNA duplexes or short hairpin RNA vectors, negatively regulatesgene expression in a sequence-specific manner. This technology is comprised of a method to use RNAi toselectively reduce levels of an actin cytoskeletal regulatory protein, cofilin1, to enhance specific productivity of recombinant proteins in CHO cells.
- *Abstract
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None
- *Inquiry
- Denise BierleinUniversity of DelawareOffice of Economic Innovation and PartnershipLicensing AnalystTelephone: (302) 831-4005Email: deniseb@udel.edu
- *IP Issue Date
- None
- *IP Type
- Utility
- 国家
- United States
- 申请号码
- Patent Pending
- 国家/地区
- 美国
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