Selective Human Sirtuin-2 Inhibitors, the Therapeutic Candidate for Huntington's Disease
- 技术优势
- More potent and selective than previous human sirtuin-2 inhibitors Improved pharmaceutical properties and promising drug candidate
- 详细技术说明
- Selective human sirtuin-2 inhibitors for use in treating Huntington's disease. #therapeutics #cns #huntingtonsdisease
- *Abstract
-
Northwestern researchers have discovered a new series of selective human sirtuin-2 inhibitors which show excellent neuronal protection in the Huntington's disease model. Human sirtuin-2 is a therapeutic target of numerous age-related neuronal degenerative diseases, including Huntington's disease, Parkinson's disease, and Alzheimer's disease. These new compounds were developed using pharmacophere exploration and SAR analysis of a lead compound. This group exhibits improved potency, selectivity and bioavailability and thus are expected to exhibit a promising pharmacological profile.
- *Inventors
- Richard B. Silverman* Hua Wang Mohammad Khanfar
- *Publications
- Bioorganic & Medicinal Chemistry Letters. 2012;22(8): 2789-2793.
- 国家/地区
- 美国
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