Native Chemical Ligation in Biocompatible Hydrogels Useful for Wound Healing and Drug Delivery
- 技术优势
- Nontoxic Can form in situ from a liquid precursor with rapid crosslinking
- 详细技术说明
- Native cross-linking hydrogels for implants, tissue support, and other medical uses#chemical #therapeutics #devices
- *Abstract
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Because their properties are similar to those of human tissues, hydrogels have been widely used as implantable medical devices. There is a medical need for hydrogels that can be put into place through minimally invasive means and those that solidify under physiological conditions. A native chemical ligation method was previously developed that achieved this cross-linking, but the process released a by-product that was potentially toxic to cells. Northwestern researchers have reworked this native chemical ligation method to achieve a single product without the release of toxic smaller molecules. The hydrogels composed of these products can be used for a variety of medical applications, including tissue repair, wound healing, drug delivery, device coating, and biosensors.
- *Inventors
- Bi-Huang Hu Jing Su Phillip B. Messersmith*
- 国家/地区
- 美国
