Polymer Hydrogel for Treatment of Age-Related Macular Degeneration (10079)
- 详细技术说明
- Key Benefit: Anovel technology with the potential to restore the effects of wet and dryage-related macular degeneration (AMD) and reverse the progression of thedisease. This approach is an entirely new method for treating AMD and may beconsidered a complimentary approach to therapies on the market and indevelopment.
- *Abstract
-
The University of Louisville is seeking a companyinterested in commercializing a novel technology that reconstruct the damaged retinaltissue caused by age-related macular degeneration. There is not currently acure for age-related macular degeneration, a disease that affects more than1.75 million people in the United States. The novel technology is aninjectable, biomimetic polymer that seals the subretinal space while providinga substrate for the healing of the retinal cells. This substrate can also beused as a vehicle for delivery of anti-angiogenic compounds and cellular reconstructionof the damaged retina. Thus, this technology could potentially restore thevision of the millions of people affected with the disease.
ADVANTAGES
■ Addresses the market need of a treatment for dryage-related macular degeneration since a treatment is not currently available
■ Hydrogel system proposed to be implanted duringone surgical procedure
■ Expected to be more cost effective than currentmethods of therapy which require multiple therapeutic applications orprocedures and address a wider range of patient population suffering fromage-rleated macular degeneration.
■ Used with transplanted cells or with nativecells that can migrate and re-epithelialize thus preventing immune responsesand cell rejection
■ Injectable and therefore can correct any sizeand shape defect in each patient
TECHNOLOGY
The Bruch’s membrane,the innermost layer of the choroid is an integral structure of the eye actingas a blood-retinal barrier and a support structure to the choroid. The Bruch’smembrane thickens with age causing numerous structural changes such asincreased thickness, deposition of extracellular matrix and lipids, collagencross-linking, elastin fragmentation and formation of advanced glycation endproducts. The polyethylene glycol based hydrogel developed by the University ofLouisville can fill in the uneven defects of the Bruch’s membrane and create aneven surface for cell population. The hydrogel is formulated to contain optimumamount of extracellular anchoring molecules and growth factors to optimize retinalpigment epithelium cell survival and resurfacing. The hydrogel is aninjectable, minimally invasive, biomimetic, in situ polymerizable substrate forreconstructing the aged Bruch’s membrane that may restore human retinal pigmentepithelium cell function and potentially restore vision.
INTELLECTUAL PROPERTY
PCT/US2011/033072 Filed April 19, 2011.
CONTACT
For additional information, please contact University of Louisville's Office of Technology Transfer:
Telephone: (502) 852-2965
Email: thinker@louisville.edu
Website: http://louisville.edu/thinker
Reference Disclosure No.10079
- 国家/地区
- 美国
