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Endovascular Exclusion Balloon Catheter for Rapid Cold Preservation of Donor Organs

详细技术说明

None

*Abstract

BackgroundIn the United States, the need for donor organs surpasses the supply by fourfold. Donation after cardiac death represents a growing source of organs and yet perhaps, the least desirable. It is mandatory that the heart stops for two to five minutes prior to incision. As a result of interval poor perfusion, many organs are lost or damaged.Technology DescriptionThe design of the current system included two interconnected catheters each with dual balloons and dual lumens that are inserted through a needle based groin access. A donor on life support would have the device placed by a minimally invasive needle approach into the femoral artery and femoral vein, with two balloons positioned above and below organ vessels. A primary lumen would shunt blood flow from the heart back to the heart in a continuous circuit. The inflated balloons would create an isolated perfusion segment for cold preservation or alternately warmed oxygenated blood from a second lumen. In summary, a Rapid Organ Preservation Catheter could be used to perfuse donor organs without impacting the natural cardiac death of a transplant donor.Applications-A Rapid Organ Preservation Catheter would primarily be used among Donation after Cardiac Death (DCD) donors to preserve organ function and increase the pool of healthy donor organs for transplant.-In addition to use during planned withdrawal of life support, this device would also have utility in cases of donors who expire prematurely before a donor surgical team is available. This would allow for organ preservation until organ explant.-Finally, this catheter could be used for instantaneous endovascular cold perfusion of organs during survival surgery, such as during cardiac or proximal vessel repairs when prolonged cessation of blood flow may otherwise risk organ damage.Advantages-An increase the number of high quality organs for transplant-A reduction of billions of dollars of medical expenses-Lives saved-Best outcomes for patientsStage of Development-In vitro data, in vivo data, animal studies-Prototype availableIP StatusPCT Application filed (PCT/US2014/068116)

*Principal Investigation

Name: Amit Tevar

Department: Med-Surgery

Name: Bryan Tillman

Department: Med-Surgery

国家/地区

美国