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Regradable Polyurethanes That Incoporate Biologically Active Agents for Bone Tissue Engineering Use

详细技术说明

None

*Abstract

A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group --X which is a hydroxyl group (--OH) or an amine group (--NH.sub.2). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is derived from a diurethane diol and is biodegradable into biomolecule degradation products.

*Principal Investigation

Name: Eric Beckman, Professor

Department: Chem/Petroleum Engineering

Name: Jeffrey Hollinger, Professor And Director BTEC

Department: Dent Med-Periodontics/Preventive Dentistry

Name: Jianying Zhang, Research Associate

Department: Med-Orthopedic Surgery

国家/地区

美国