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Episomal Expression Cassettes For Gene Therapy

总结

The Invention Consists Of Episomal Expression Cassettes For Expression Of A Transgene In Gene Therapy. The Expression Cassettes Consist Of Regulatory Elements Of The Human Cytokeratin Gene And A Transgene. The Invention Also Includes Of Liposomes For Transfection Of Epithelial Tissue With The Cassettes In Treatment Of Cystic Fibrosis, Emphysema, Cancers Of Epithelial Origin Arising In The Lung Or Other Organs.

附加资料

Patent Number: US6372500B1
Application Number: US1999423744A
Inventor: Hu, Jim | Chow, Yu Hua | O'Brodovich, Hugh | Tsui, Lap Chee
Priority Date: 14 May 1997
Priority Number: US6372500B1
Application Date: 12 Nov 1999
Publication Date: 16 Apr 2002
IPC Current: C07K001447 | C12N001512 | C12N001585 | A61K004800
US Class: 435455 | 42409321 | 4353201 | 435325 | 435366 | 514044R | 514044
Assignee Applicant: HSC Research and Development Limited Partnership,Toronto
Title: Episomal expression cassettes for gene therapy
Usefulness: Episomal expression cassettes for gene therapy
Summary: USE EC, and the liposomes, are used in gene therapy of lung diseases (by delivery to submucosal pulmonary epithelial cells), specifically cystic fibrosis (CF) but also epithelial cancers and emphysema (e.g. where (I) expresses an angiogenesis inhibitor or interleukin-10). Other uses include research (in vitro or in animal models); producing proteins, and gene therapy of other diseases, e.g. cancer of colon or breast, including expression of antisense sequences.
Novelty: New episomal expression cassette for expressing transgene in epithelial cells liposomes and transfected cells containing it, and transfected lung tissue, especially for gene therapy of cystic fibrosis

主要类别

生物医学

细分类别

DNA /基因工程

申请号码

US1999423744A

国家/地区

香港