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Improved Microelectrode Array for Neural Recording

IP Title
MEMS Flexible Substrate Neural Probe
Detailed Technology Description
None
Supplementary Information
Inventor: Chen, Genda | Drewniak, James L. | Mu, Huimin | Pommerenke, David
Priority Number: US7421910B2
IPC Current: G01L000104
US Class: 073862451 | 340665
Assignee Applicant: The Curators of the university of Missourilumbia
Title: Strain sensitive coax cable sensors for monitoring structures
Usefulness: Strain sensitive coax cable sensors for monitoring structures
Summary: For use in electrical time domain transmission or electrical time domain reflectometry system to detect and measure strain in associated structure e.g. building, bridge, road, dam.
Novelty: Strain sensitive coax cable sensor for monitoring structure, has deformation unit associated with outer conductor to create localized deformation that creates electrically detectable inductance change with respect to outer conductor
Industry
Architecture/Construction
Sub Category
Construction Engineering
Application Date
Sep 10, 2007
Application No.
8,170,638
Others
*Abstract

Alleviates Strain During Neural Surgery to Minimize Tissue Damage

This neural microelectrode leverages the recording properties of conventional micro-wire electrode arrays with additional features such as the precise control of the electrode geometries and bond pad sites and flexible materials via micromachining. Electrode arrays have high neuronal yield, which improves the accuracy and performance characteristics such as impedance and signal to noise ratio providing competitive advantage. Micro-wire electrodes have been extensively used for acute and chronic applications of neural recording. However, they are assembled from discrete components and prove challenging to integrate with circuitry. For brain machine interfaces, the ultimate application of a fully implantable device warrants the need for integration between the amplifiers and electrode arrays.

Application

Neural recording device for development of a set of neurotherapeutic devices that computer control prosthetic limbs and devices

Advantages

  • Flexible cable design alleviates strain from external connector minimizingchronic tissue damage and patient complications
  • Electrodes are designed to pierce through neural tissue during implantationsurgery without buckling
  • Metal traces and corresponding bond sites can be made to any size specifica-tion and spacing distance via photolithography and thus can be used inmultiple custom application-specific-integrated circuits

Technology

A flexible substrate microelectrode array has been designed using micro-fabrication techniques and tested in vivo. The neural probe array consists of eight probes with gold-plated electrode sites on the tip that protrude from a flexible cable. The benefits of the micro-fabrication design allows for tailoring the electrode geometry for neuronal structures of interest. High channel count arrays are constructed by layering the proposed design. The flexible cable additionally provides strain relief from the fixed external connection, which will minimize tissue damage from external forces. Due to the adaptability of the fabrication process metals such as platinum may be readily incorporated.

*IP Issue Date
May 1, 2012
*IP Publication Date
Dec 3, 2009
*Principal Investigator

Name: Toshikazu Nishida

Department:


Name: Erin E Patrick

Department:


Name: Justin Sanchez

Department:

Country/Region
USA

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