Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over- expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered.....
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Methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.
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(-)-EGCG是最丰富的儿茶素，其被认为是化学预防及抗癌剂。然而，(-)-EGCG具有至少一个局限性：其生物利用度差。本发明提供了具有下列通式的化合物，其中R11、R12、R13、R21、R22、R2、R3和R4均各自独立地选自-H和C1-C10酰氧基；以及R5选自-H、C1-C10烷基、C2-C10烯基、C2-C10炔基、C3-C7环烷基、苯基、苯甲基和C3-C7环烯基，同时，最后提到的7个基团中的每一个都可用1到6个卤素原子的任意组合取代；R11、R12、R13、R21、R22、R2、R3和R4中至少有一个是-H，这些化合物被证实比其用作蛋白酶体抑制剂以减少肿瘤细胞生长的未被保护对应物更.....
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This invention introduces a new method of using an anthraquinone derivative or known as Rhein, for treating chronic pancreatitis. It is notably that Rhein or extracts from Polygonaceae (rhubarb) is a potential anti-fibrotic agent without giving any adverse effects in the animal study. Most important.....
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ZnO-NPs exhibit a strong preferential ability to kill cancerous cells compared to healthy tissues. Key research findings show that ZnO-NPs induce toxicity in a cell-specific and proliferation-dependent manner, with rapidly dividing cells being the most susceptible and quiescent cells being the least.....
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