Lead Inventors: Lawrence ShapiroProblem or Unmet Need:The drug development of energy balance disorders, such as obesity and type-2 diabetes, is limited by lack of detailed understanding of metabolic control. A key target in this area is the adenosine monophosphate-activated protein kinase (AMPK) com.....
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Thetechnology is a method of blockading CTPS1 as a target for therapeutics intreating neointima-related disorders. Specifically, the invention aims to be vascularsmooth muscle specific anti-proliferative drugs for the next-generation drugeluting stents. Vascular remodeling as a result of smooth musc.....
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This technology follows a process that enables the production of flexible and transparent substrates such as mono-crystalline silicon that can be used as a platform for semiconductor printing and wiring in electronic devices. The process is cost-effective and can be made compatible with the conven.....
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It is estimated that about one in fifty people have an unruptured brain aneurysm in the United States alone. Endovascular coiling is one of the most common minimally invasive treatment for cerebral aneurysms. However, aneurysm geometry is highly patient-specific, and commercial coils come in pre-def.....
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Where current adjuvants act by one or several of the following mechanisms, the Th17-class of adjuvants mediate all of the following: Increase antigen transport and uptake (phagocytosis) by antigen-presenting cells Provide a long-lasting depot effect, i.e., antigenic reservoir .....
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