A synergistic increase in apoptosis occurs when myeloproliferative neoplasm primary cells are treated simultaneously with inhibitors of BRD4 and JAK2, and when AML cell lines are treated with inhibitors of BRD4 and FLT3. Moreover, in vitro studies suggest that JAK1/JAK2 inhibitor resistant cells re.....
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This chitosan derivative may be used to deliver prokaryotic gene silencing CRISPR RNA as a possible treatment for drug resistant infections. Upon acidification, the native chitosan is released. This native chitosan may then damage the bacterial cell membrane and/or interrupt bacterial biological p.....
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This technology provides the following significant improvements over previous cholera vaccines
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The potential of cucurbitacins and their analogs as lead drug candidates for the treatment of prostate cancer. The compounds developed have the potential to reduce cancer resistance through stronger androgen receptor binding as well as perform better than the current treatments in the marketplace an.....
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