The Present Inventors Have Discovered That 3-Isopropylmalate Dehydratase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of 3-Isopropylmalate Dehydratase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, 3-Isopropylmalate Dehydratase Can Be Us.....
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The Present Inventors Have Discovered That Alpha-Aminoadipate Reductase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of Alpha-Aminoadipate Reductase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, Alpha-Aminoadipate Reductase Can Be Used .....
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Neutrophil elastase (NE) is a protease secreted by neutrophils during inflammation. Aberrant expression of NE such as in chronic respiratory inflammatory diseases, results in tissue destruction and decline in lung function. Compositions including an NE-targeting agent that targets the pathologic ele.....
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