Neurodegenerative diseases, such as Parkinson’s, Alzheimer’s, and Huntington’s, are characterized by misfolded proteins that aggregate and induce neuronal toxicity and death. Protein disulfide isomerase (PDI) is an enzyme implicated in protein misfolding and has been shown to be upregulated in the b.....
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Technology: Researchers at MUSC have identified multiple gene variants that are critical for the response to opioid receptor antagonists, including naltrexone for AUD. First, recent work has further validated that carriers of OPRM1 asp40/ DAT10 variable number tandem repeat (VNTR) and asn40/ DAT9 va.....
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System xC- is a cysteine/glutamate antiporter whose inhibition induces ferroptotic cell death. Therapeutic inhibition of system xC- for targeted cell death in certain cancers has previously been stymied by the low potency and poor pharmacokinetics of known inhibitors. This technology identifies the .....
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Cuts transaction time on I/O bus in halfEnables multiple sector write mode and real-time Metadata updating ·Lower energy overhead
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