Mouse model for immune system malignancies in B, T and granulocytes cells. Mouse model for B-cell selection, development, maturation, antibody production and signaling responses through PI3-kinase pathways. Mouse model for designing therapeutics against B-cell malignancies and preventing autoantib.....
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The invention discloses a full genesequence for the novel nitrate reductase NR2, and identifies the composition ofits gene variants. The mechanism of action of NR2 is shown to be a novel methodfor the detoxification of nitric oxide. This process is done with greaterefficiency and in a more environme.....
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Johri A et al. (2012) Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease. Hum Mol Genet. 2012 Mar 1;21(5):1124-37.
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• Focuses solely on TRPV3 as a cancer target• Camphor is a widely available small molecule with documented safety profile• Reduced toxicity can lead to greater therapeutic window and patient compliance• All other approved non-surgical treatments for high-risk are systemic and have severe side effect.....
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