Oligonucleotide-based aptamers can selectively bind with high affinity to target molecules, and systematic evolution of ligands by exponential enrichment (SELEX) can be used to screen for and amplify the desired aptamer. However, some simple target molecules with few functional groups, like glucose .....
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This technology describes a method for treating ID2 protein-related diseases through increased degradation of Hypoxia-Inducible Factors (HIFs).
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Inventor: Sarah C. LarsenAssociate Professor, Department of ChemistryAssociate Director of Nanoscience and Nanotechnology Institutehttp://ccs14.chem.uiowa.edu/faculty/larsen/group/group.html
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The proposed technology is a novel set of fluorouracil derivatives, obtained from the dimerization of 5-FU. These derivatives are expected to have improved chemical properties in treating cancer. The technology also includes a novel synthetic method to obtain these derivatives. This method has great.....
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