The tumor: Malignant primary brain tumors and especially the highly malignant Glioblastoma Multiforme (GBM) are fatal within months of diagnosis in almost all patients. There are more than 20,000 patients in the US and approximately 200,000 patients worldwide that are diagnosed annually with maligna.....
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We have developed an ELISA-based immunoassay that measures the levels of two proteins in the blood, Mortalin/GRP75 and HSP70, identifying colorectal cancer patients at high risk of poor survival.Mortalin/GRP75, is a ubiquitous mitochondrial chaperone related to the cytosolic heat shock protein 70 (H.....
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ER stress, elicited by chemotherapeutic agents such as doxorubicin, 5FU, vincristine and bortezomib, or statins such simvastatin, triggers cell death at least in part through generation of leukotriene C4 (LTC4), which induces ROS accumulation, DNA damage and subsequent cell death. LTC4 can be produc.....
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Improvement of protein production by modulating the tRNA pool. For maximal heterologous expression of proteins per host cell, the optimal level of expression of genes needs to be addressed. The science and art of expressing a gene from one species in another often amounts to modifying the codons of .....
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All heavy machinery relies on large shafts to convey rotary motion. A small shaft crack, if not detected in time, can cause instability which can render the machine unusable and in rare cases even explode. Current methods for locating faults in turbine shafts and generator rotors require either stop.....
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