Membrane proteins (MP) mediate many of the cell’s fundamental processes and MPs are embedded in the cell’s membrane lipid bilayer. Currently, MPs are targets for about 60% of therapeutic drugs in use. However, MPs are very difficult to manipulate and study because they require both an aqueous enviro.....
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CAMH scientists have identified an interaction between dopamine transporter DAT and the presynaptic dopamine type 2 receptor (D2) which is thought to be an underlying cause for Attention Deficit Hyperactivity Disorder (ADHD). By characterizing this interaction, our scientists have developed a peptid.....
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Our scientists have identified a previously unrecognized molecular pathway involving a series of protein‐protein interactions that underlies glutamate (GluR2) containing - α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) receptor mediated excitotoxicity as a novel target for treatment of .....
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