This invention provides: New therapeutic options for the treatment of cancers that overexpress HER-2/neu. New insight into the mechanism by which HER-2/neu overexpression leads to cancer. Methods to gain valuable information useful for the diagnosis and prognosis of cancer.
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A series of novel derivatives of phosphonate compounds has been synthesized. These novel compounds have demonstrated enhanced activity against poxviruses and herpes viruses in tissue culture cells when compared with the unmodified parent molecules. When evaluated against existing alkoxyalkyl analogs.....
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The use of this technology provides extremely accurate measurements of proteins by minimizing procedural errors due to unstable labeling of peptides to be measured. With improved peptide labeling as described in this technology, mass spectormetry-based proteomic analysis circumvents running laboriou.....
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Matrix metalloproteinases (MMPs) are a class of zinc-dependent hydrolytic enzymes that function in the degradation and restructuring of extracellular proteins. Overexpression of MMPs has been associated with a variety of diseases, including cancer, arthritis, and cardiovascular disease. Commercializ.....
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Hydrophilic conversion reduces friction between device and catheter during insertion or delivery; hydrophilic properties not easily reversed Increased affinity between the device and vascular tissue, resulting in accelerated healing and reduced clotting
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