Predicts efficacy and response of dasatinib therapy on triple negative breast cancer subtypes Genes expressed in patients with specific breast cancer subtypes may be sensitive to therapy with SRC kinase inhibitors Predictive markers may be used in clinical development of compounds to treat solid t.....
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Rationale: geranylgeranylation of Ras proteins is a key escape pathway for oncogenic cells treated with farnesyl transferase inhibitors (FTIs). Small molecule antagonists of GGTaseI are therefore promising candidates for fully blocking activation of Ras.Leads: Both UC22 and UC23 are drug-like compo.....
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Novel, small molecule modulators of endothelial-triggered immune responses. The compounds induce effective immune responses with minimal gene activation, theoretically reducing damaging effects of excessive IFN-γ stimulation.
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Main Advantages of this InventionΓÇó Cost-effectiveΓÇó EfficientΓÇó Inert to downstream processes
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Advantages:Simultaneously measure all human MT isoforms, with sensitivity to detect single amino acid differencesQuantify relative or absolute levels of all MT isoforms by Mass Spec, including post-translational modificationsUse for research, diagnosis/prognosis of cancers, and monitoring heavy meta.....
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