This new cross-linker allows for the MS analysis of multi-subunit protein complexes. In addition, the accompanying software package allows for the fast and accurate identification of DSSO-cross-linked peptides via MS.
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The advantages of this new technique are: a. Increased Accuracy; b. Increased Spatial Resolution; c. No Tissue Contact Required;
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The system is highly flexible. It can:be designed to detect virtually any protease activity of interest;be designed to target proteases located in membranes or vesicles; andaccommodate any measurable reporter protein. The system can be used to observe proteolytic activity in vitro and in vivo in .....
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The present invention can be used in cell culture applications for isolating and distributing small groups of cells for further culturing. Single cell droplets can be replated at clonal density and processed in an automated and complex fashion, while multiple cell droplets can be fused and cultured.....
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