Reduced immunogenicity Interacts with the human immune system Reduces tumor volume by ~29% in mice
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Investigators at St. Jude Children's Research Hospital have discovered the IKZF1 gene, which encodes the Ikaros transcription factor, is deleted in a majority of BCR-ABL1 positive acute lymphoblastic
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70% of the nearly $1 billion spent on bringing each new small-molecule anticancer drug to market is spent on clinical trials. A significant part of this cost is attributed to the failure of many drugs early on in trials due to lack of efficacy. While animal models can help predict clinical efficacy .....
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