Alkylating agents are the most widely used anticancer drugs. Drug resistance is a major obstacle in the successful treatment of cancer by alkylating agents. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) has been implicated in resistance of human tumors to alkylating agents. .....
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Background:Glaucoma is a disease characterized by intra-ocular pressure sufficient to damage the optic nerve and cause permanent impairment of vision. Glaucoma is rarely cured, but its progression can be greatly delayed by reducing the intra-ocular pressure with medicines, laser procedure or surgery.....
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