Lead Inventors: Julio M. Fernandez, Ph.D.Problem or Unmet Need:Chemical reactions involving bond cleavage can be detected using a variety of spectroscopic techniques. However, they are always detected in bulk or through coupled reactions, thus preventing examination of population heterogeneities or .....
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This invention is a new folded differential pair topology made from floating-gate MOS transistors.
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Based on the fact that Hg_+ can bind in between T-T mismatches in DNA and stabilize the T-T mismatches, while other metals cannot, this sensor has a detection limit of 2.4 nM, which is lower than the EPA limit of Hg_+ in drinking water.
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