New conjugation of cryptophycins for use in ADC (antibody-drug conjugates) and SMDC (small molecule drug conjugates)
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New route to protein-coupling via intein trans-splicing in the absence of reducing agents . Inteins are protein domains that auto-catalyze protein-splicing of their flanking regions with a peptide bond.In this invention novel cysteine-less split inteins are capable of robust trans-splicing at ambien.....
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The dramatic speedup of measurements will result in a more economic use of expensive lab equipment and personnel and allow for the measurement of even weaker signals on a noise background.
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Generation of coherent light of high intensity in a solid state "cold Laser"
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