Method of synthesizing Id-KLH is simple and inexpensive Avoids over-conjugation and destruction of critical immunogenic protein motifs Demonstrated superiority of maleimide Id-KLH conjugates over glutaraldehyde Id-KLH conjugates to develop more efficacious vaccines
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Small (18 amino acids) Non-hemolytic, and virtually noncytotoxic in vitro. Defined mechanism of action against HIV-1 (entry inhibition). Potentially synergistic with other immune-system components, including alpha defensins,protease inhibitors, reverse transcriptase inhibitors, etc.
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The given technology involves the use of a PTD-DRBD (peptide transduction domain-dsRNA binding protein) fusion peptide. DRBD binds siRNAs with high avidity independent of its sequence and allows PTD-mediated cellular uptake. PTD-DRBD mediated siRNA delivery occurs by a specialized process of macropi.....
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Although algorithms and chemistries for developing new therapeutic entities are constantly evolving, none can replicate the path and novelty of natural selection over eons of time. Inventors at the Scripps Institution of Oceanography have engaged their fleet of research ships to cull .....
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The HOMPS genes represent novel targets for the development of diagnostics and therapeutics for breast and ovarian cancer.
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