Scientists at UC San Diego have addressed these shortcomings and developed a high-content, high-throughput chemical screening method that is based on a signature of gene expression. This signature-based drug screening strategy overcomes key drawbacks associated with current cell-based assays. The pr.....
[更多]
• Compatible with nanofluidic proteomic assays, which enable automated and more sensitive detection of isoform variants• Novel biomarkers of response in validated primary cancer stem cell populations• Can confirm mechanism of action and synergistic activity (i.e. JAK2 and BCR-ABL inhibitors)• Uses b.....
[更多]
Can be used with high specificity to modulate the talin-integrin beta-sub3 interaction without the side effects that may occur with presently available therapeutic agents and methods. Offers a new screening method to detect agents that block integrin beta-sub3 activation, as well as a method for scr.....
[更多]
The peptide can be made synthetically, produced in high quantities at GMP quality, and lyophilized without a loss in activity. It is inexpensive and naturally biodegradable. The peptide can be genetically engineered to DC targeting molecules like DEC-205, which promotes strong immune responses w.....
[更多]
| |< <- | [62] [63] [64] [65] [66] [67] [68] [69] [70] [71] [72] | -> >| |
