Simplified scaffold affords the creation of a population of binding proteins with highly diverse binding specificities and affinities through the modification of a single polypeptide chain. Optimized profile of variable residues within the CLec-fold scaffold, which are manipulable without influe.....
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A series of novel lipid derivatives of phosphonate compounds has been synthesized. These novel compounds have been shown to promote oral uptake and increase delivery of the conjugate to the lung in animal models when compared with the parent compounds. A similar derivatization strategy can also be a.....
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This technology would improve respiratory function in patients with spinal cord injuries.
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Inhibits the HMGCR pathway through a different mechanism than statins. Identifies probes specific to a phenotype of interest and thus does not require prior target identification and validation.
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Type I Diabetes
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