Enhancement of the therapeutic effect of antisense treatments that are currently too inefficient to be effective The compounds were derived from FDA-approved libraries of known biologically active molecule libraries
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High reproducibility; Significantly reduced damage to cells under study; and, Rapid identification and sorting of single cells on the basis of distinct subcellular biology.
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The immune response plays a critical role in protecting humans and animals from infection and the development of tumors. Compositions that increase the immune response (adjuvants) are therefore valuable for improving vaccine efficacy and the control of tumor growth and metastasis. Novel combination.....
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Rationale: geranylgeranylation of Ras proteins is a key escape pathway for oncogenic cells treated with farnesyl transferase inhibitors (FTIs). Small molecule antagonists of GGTaseI are therefore promising candidates for fully blocking activation of Ras.Leads: Both UC22 and UC23 are drug-like compo.....
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Main Advantages of this InventionΓÇó Cost-effectiveΓÇó EfficientΓÇó Inert to downstream processes
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